Mise à jour le   25/05/2023


CalciScreen is a R&D and Services core facility dedicated to the identification of Ca2+ signaling modulators for therapeutic applications.


CalciScreen is the first core facility in Europe to offer services from in vitro to in vivo preclinical phases in the field of Ca2+related diseases.


CalciScreen brings together the means and expertise, at the interface between chemistry and biology, of 3 French laboratories located in Brest, Tours and Orléans.


> Skills

1.   Screening of Ca²+ flux modulators - Brest
2.    CA²+ sensitive channels activities - Tours
3.    Custom chemical synthesis services (Synthèses de références, optimisation de composés prometteurs, conception de sonde, criblage de chimiothèque, chimie analytique, modélisation moléculaire et criblage in silico) - Orléans

This technological platform allows a reasoned screening of synthetic or natural compounds that modulate calcium signaling.


> Equipment

Screening of Ca²+ flux modulators - Brest
•    Flextstation station (Molecular Device)
•    Videomicroscope
CA²+ sensitive channels activities - Tours
•    Automated patch-clamp station (Nanion)
Chemistry - Orléans
•    Flow Chemistry
•    H-Cube
•    Scale-up platform
•    RMN 250/400/600/700 Mhz
•    Mass Spectrometry: Maldi-Tof, Q-Tof, sources ESI, ACPI, APPI
•    Chromatography: HPLC, nano-LC, UPLC, SFC, GC, EC, HPTLC, CPC
•    Detector Light Scattering: DEDL
•    Scientific computer cluster: CPU PowerEdge R710 and clusters cards GPU K80 and TitanZ



Calciscreen services and expertise are offered to both academic and industrial entities.

Download the presentation brochure




Real time imaging of Ca 2+ fluxes in single living cells using fluorescence
video microscopy and image analysis. Brest site.