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Machine learning identifies a common signature for anti-SSA/Ro60 antibody expression across autoimmune diseases

Autoantibodies are markers of autoimmune diseases. The most frequently observed is the anti-SSA/Ro autoantibody. It is observed in Gougerot-Sjögren syndrome, systemic lupus erythematosus, undifferentiated connectivites but also sometimes in rheumatoid arthritis and scleroderma. Using artificial intelligence approaches on multi-omics data [...] Read more...

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  • Foulquier N, Le Dantec C, Bettacchioli E, Jamin C, PRECISESADS Clinical Consortium, PRECISESADS Flow Cytometry Consortium, Alarcón-Riquelme Marta E and Pers JO. Machine learning identifies a common signature for antiSSA/Ro60 antibody expression across autoimmune diseases. Arthritis & Rheumatology 2022. doi: 10.1002/art.42243

 

  • Le Rochais M, Hemon P, Pers J-O and Uguen A (2022) Application of High-Throughput Imaging Mass Cytometry Hyperion in Cancer Research. Front. Immunol. 13:859414. doi: 10.3389/fimmu.2022.859414

 

  • Michée-Cospolite M, Boudigou M, Grasseau A, Simon Q, Mignen O, Pers J-O, Cornec D, Le Pottier L and Hillion S (2022) Molecular Mechanisms Driving IL-10- Producing B Cells Functions: STAT3 and c-MAF as Underestimated Central Key Regulators? Front. Immunol. 13:818814. doi: 10.3389/fimmu.2022.818814

 

  • Laigle L, Le Dantec C, Soret P, Desvaux E, Hubert S, Foulquier N, Moingeon P, Guedj M and Pers JO (2022) Sjögren’s syndrome: Towards precision medicine. Med Sci (Paris) 2022 ; 38 : 148–151. doi: 10.1051/medsci/2021258

The UMR1227 'B Lymphocytes and Autoimmunity' brings together several clinical entities around the immunology laboratory.

Rheumatology, haematology, nephorology and odontology for a scientific project articulated around two main complementary and interconnected axes: an axis dedicated to the understanding of the mechanisms that govern the functional orientation of B cells in autoimmunity, and a translational axis aiming at developing new tools to improve the efficiency of B-cell targeting immunotherapies, while working on a better stratification of patients, a better understanding of the mode of action of these therapies, and the development of these therapies and innovative therapeutic strategies.

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