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target-therapy

Spatially targeted eradication of antimicrobial-resistant bacteria

Equiment

Mise à jour le   03/02/2026

  1. Molecular biology & genomics
    - Conventional PCR and real time qPCR systems
    - DNA/RNA electrophoresis equipment
    - Quantification instruments (Nanodrop)
    - Bioanalyzers (TapeStation / BioAnalyzer)
    - Library preparation workstations
    - Refrigerated centrifuges and microcentrifuges
    - −80 °C freezers
    - Liquid nitrogen cryopreservation systems

     

  2. Cell culture & microbiology
    - Dedicated cell culture rooms
    - Class II biosafety cabinets (PSM2)
    - CO₂ incubators
    - Standard optical and fluorescence microscopes, including Nikon Ti2 E inverted microscope (high resolution live cell imaging, motorized stage and automated acquisition, compatible with fluorescence and time lapse studies)
    - Microbial culture equipment (bacteriological incubators, spectrophotometers)

     

  3. Vectors, nanoparticles & chemistry (GTCA team)
    - Zetasizer devices, including Malvern NanoSight NS300 (Nanoparticle Tracking Analysis (NTA), Particle size distribution (10 nm–1 µm) and concentration measurement, suitable for extracellular vesicles, viruses, liposomes, polymeric nanoparticles)
    - Equipment for synthesis and formulation of non viral vectors
    - Purification and physicochemical characterization systems

     

  4. Additional internal resources
    - Facilities for functional genetics (yeast models, splicing assays)
    - Internal servers for bioinformatics analyses
    - DNA/RNA biobanks managed within the unit

  1. Shared animal facility (UBO)
    - Facilities for hosting conventional and infected rodents (mice, rats)
    - Controlled access housing with regulated temperature, humidity, and light cycle 

    - Bioluminescence imaging (BLI) system for in vivo monitoring
    - Anesthesia equipment (isoflurane vaporizer, induction chamber, monitoring systems)
    - Dedicated surgery room for small animal procedures
    - Biosafety level 2 (BSL 2) environment for infection studies
    - Equipment for sample collection and necropsy (biosafety cabinets, dissection tools)

     

  2. Imaging & microscopy platform (UBO)
    - Optical and fluorescence microscopy
    - Confocal microscopy
    - Live cell imaging systems
    - Morphometric and quantitative imaging tools

     

  3. NMR / EPR platform (UBO)
    - Nuclear magnetic resonance
    - Electron paramagnetic resonance
    - Structural and molecular analysis

     

  4. Mass spectrometry platform (UBO)
    - LC MS/MS
    - Analysis of small molecules, peptides, and metabolites

     

  5. Sequencing & genomics platform (UBO / CHRU)
    - Illumina NGS sequencers
    - Sanger sequencing
    - Automated library preparation systems
    - Shared bioinformatics pipelines

     

  6. Microbiology / metagenomics platform (UBO)
    - 16S and shotgun metagenomic sequencing
    - Microbiome analysis
    - Microbial phenotyping tools

     

  7. High performance computing & bioinformatics (UBO)
    - HPC servers
    - Shared computational environments
    - Support for genomic, transcriptomic, and metagenomic analyses